8dfr Summary

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REFINED CRYSTAL STRUCTURES OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE. 3 ANGSTROMS APO-ENZYME AND 1.7 ANGSTROMS NADPH HOLO-ENZYME COMPLEX

A publication describing this structure is not available. The depositing authors are Matthews, D.A.search; Oatley, S.J.search; Burridge, J.search; Kaufman, B.T.search; Xuong, N.-H.search; Kraut, J.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of DIHYDROFOLATE REDUCTASE. This molecule has the UniProt identifier P00378 (DYR_CHICK)search. The sample contained 189 residues which is 100% of the natural sequence. Out of 189 residues 186 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DIHYDROFOLATE REDUCTASE P00378 (1-189) (DYR_CHICK)search Gallus gallussearch 100% 189 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00378 (1 - 189) DIHYDROFOLATE REDUCTASE Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00378) Dihydrofolate reductasessearch Dihydrofolate Reductase, subunit Asearch PF00186: Dihydrofolate reductasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P00378) RNA bindingsearch drug bindingsearch dihydrofolate reductase activitysearch NADP bindingsearch oxidoreductase activitysearch mRNA bindingsearch tetrahydrofolate biosynthetic processsearch glycine biosynthetic processsearch nucleotide biosynthetic processsearch oxidation-reduction processsearch response to methotrexatesearch one-carbon metabolic processsearch tetrahydrofolate metabolic processsearch

Chain InterPro annotation
A Dihydrofolate reductase domainsearch Dihydrofolate reductasesearch Dihydrofolate reductase conserved sitesearch Dihydrofolate reductase-like domainsearch