› 7ve3

X-ray diffraction
2.7Å resolution

Structure of the complex of sheep lactoperoxidase with hypoiodite at 2.70 A resolution

Released:
DOI: 10.2210/pdb7ve3/pdb
PDB entry 7ve3 coloured by chain, front view.
PDB entry 7ve3 coloured by chain, side view.
PDB entry 7ve3 coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase.
Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP
Protein Sci 31 384-395 (2022)
PMID: 34761444

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoperoxidase Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.7 KDa
Source organism: Ovis aries
Expression system: Escherichia coli

Ligands and Environments

6 bound ligands:
Ligand HEM 1 x HEM
Ligand CA 1 x CA
Ligand NAG 2 x NAG
Ligand IOD 6 x IOD
Ligand SO4 1 x SO4
Ligand 61D 11 x 61D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 53.942Å b: 80.179Å c: 76.122Å
α: 90° β: 102.86° γ: 90°
R-values:
R R work R free
0.199 0.195 0.277
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

A Bacterial Myeloperoxidase with Antimicrobial Properties.
Céré et al. (2023)

1 mention without citation

Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase.
Singh et al. (2022)