7kme Summary



The structure was published by Mochalkin, I. and Tulinsky, A., in 1999 in a paper entitled "Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This entry contains 10 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L THROMBIN L-CHAIN P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 69%
H THROMBIN H-CHAIN P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 97%
I HIRUGEN Not available
Not available Not available 10 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00734 (328 - 363) THROMBIN L-CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
H (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
L (P00734) serine-type endopeptidase activitysearch blood coagulationsearch proteolysissearch extracellular regionsearch
H (P00734) serine-type endopeptidase activitysearch calcium ion bindingsearch catalytic activitysearch proteolysissearch blood coagulationsearch

Chain InterPro annotation
L Thrombin light chainsearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch