› 7jz9

X-ray diffraction
1.82Å resolution

Dihydrodipicolinate synthase S48F with pyruvate and succinic semi-aldehyde

Released:
DOI: 10.2210/pdb7jz9/pdb
PDB entry 7jz9 coloured by chain, front view.
PDB entry 7jz9 coloured by chain, side view.
PDB entry 7jz9 coloured by chain, top view.
Source organism: Escherichia coli
Entry authors: Board AJ, Dobson RCJ

Function and Biology Details

Reaction catalysed: 
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxy-tetrahydrodipicolinate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 31.54 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A6L2 (Residues: 1-292; Coverage: 100%)
Gene names: JW2463, b2478, dapA
Sequence domains: Dihydrodipicolinate synthetase family

Ligands and Environments

2 bound ligands:
Ligand K 3 x K
Ligand GOL 1 x GOL
1 modified residue:
Ligand VPV 2 x VPV

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3121
Unit cell:
a: 120.919Å b: 120.919Å c: 110.081Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.145 0.143 0.171
Expression system: Escherichia coli

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