7ahl Summary

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ALPHA-HEMOLYSIN FROM STAPHYLOCOCCUS AUREUS

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Song, L., Hobaugh, M.R., Shustak, C., Cheley, S., Bayley, H., and Gouaux, J.E., in 1996 in a paper entitled "Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.89 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ALPHA-HEMOLYSIN.

The molecule most likely forms homoheptamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
B ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
C ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
D ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
E ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
F ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%
G ALPHA-HEMOLYSIN P09616 (27-319) (HLA_STAAU)search Staphylococcus aureussearch 100% 293 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09616 (27 - 319) ALPHA-HEMOLYSIN Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G (P09616) Leukocidin (pore-forming toxin)search Leukocidin-likesearch PF07968: Leukocidin/Hemolysin toxin familysearch

Chain ID Biological process (GO) Cellular component (GO)
A, B, C, D, E, F, G (P09616) pathogenesissearch cytolysissearch hemolysis in other organismsearch cytolysis in other organismsearch extracellular regionsearch

Chain InterPro annotation
A, B, C, D, E, F, G Bi-component toxin, staphylococcisearch Aerolysin/haemolysin toxin, conserved sitesearch Leukocidin/porinsearch