› 7adh

X-ray diffraction
3.2Å resolution

THREE-DIMENSIONAL STRUCTURE OF ISONICOTINIMIDYLATED LIVER ALCOHOL DEHYDROGENASE

Released:
DOI: 10.2210/pdb7adh/pdb
PDB entry 7adh coloured by chain, front view.
PDB entry 7adh coloured by chain, side view.
PDB entry 7adh coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase.
Plapp BV, Eklund H, Jones TA, Brändén CI
J Biol Chem 258 5537-47 (1983)
PMID: 6343388

Function and Biology Details

Reaction catalysed: 
A primary alcohol + NAD(+) = an aldehyde + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alcohol dehydrogenase E chain Chain: A
Molecule details ›
Chain: A
Length: 374 amino acids
Theoretical weight: 39.85 KDa
Source organism: Equus caballus
Expression system: Not provided
UniProt:
  • Canonical: P00327 (Residues: 2-375; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand NTN 23 x NTN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 177.8Å b: 61.2Å c: 56.5Å
α: 90° β: 104° γ: 90°
R-values:
R R work R free
0.29 not available not available
Expression system: Not provided

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Citations

1 review citation

Conformational changes and catalysis by alcohol dehydrogenase.
Plapp BV. (2010)
7 other articles