› 6ulp

X-ray diffraction
2.8Å resolution

BRD3-BD2 in complex with the cyclic peptide 3.2_3

Released:
DOI: 10.2210/pdb6ulp/pdb
PDB entry 6ulp coloured by chain, front view.
PDB entry 6ulp coloured by chain, side view.
PDB entry 6ulp coloured by chain, top view.
Source organisms:
Primary publication:
Cyclic peptides can engage a single binding pocket through highly divergent modes.
Patel K, Walport LJ, Walshe JL, Solomon PD, Low JKK, Tran DH, Mouradian KS, Silva APG, Wilkinson-White L, Norman A, Franck C, Matthews JM, Guss JM, Payne RJ, Passioura T, Suga H, Mackay JP
Proc Natl Acad Sci U S A 117 26728-26738 (2020)
PMID: 33046654

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167580 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15059 (Residues: 307-419; Coverage: 16%)
Gene names: BRD3, KIAA0043, RING3L
Sequence domains: Bromodomain
Cyclic peptide 3.2_3 Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.69 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 2 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I4
Unit cell:
a: 97.568Å b: 97.568Å c: 77.748Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.248
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

A Strategy Utilizing Protein-Protein Interaction Hubs for the Treatment of Cancer Diseases.
Carels et al. (2023)
9 other articles

2 mentions without citation

Cyclisation strategies for stabilising peptides with irregular conformations.
Vu et al. (2021)
1 more