› 6uld

X-ray diffraction
1.5Å resolution

Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer

Released:
DOI: 10.2210/pdb6uld/pdb
PDB entry 6uld coloured by chain, front view.
PDB entry 6uld coloured by chain, side view.
PDB entry 6uld coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydroxymethyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 447 amino acids
Theoretical weight: 47.37 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

4 bound ligands:
Ligand PLP 2 x PLP
Ligand GLY 1 x GLY
Ligand SER 1 x SER
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 63.65Å b: 60.01Å c: 101.66Å
α: 90° β: 92.993° γ: 90°
R-values:
R R work R free
0.126 0.126 0.163
Expression system: Escherichia coli BL21(DE3)

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