› 6stf

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-8A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 178 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61006 (Residues: 5-176; Coverage: 83%)
Gene names: MEL, RAB8, RAB8A
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:
Ligand GDP 5 x GDP
Ligand MG 5 x MG
1 modified residue:
Ligand SEP 5 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 117.55Å b: 75.18Å c: 107.7Å
α: 90° β: 100.48° γ: 90°
R-values:
R R work R free
0.234 0.233 0.262
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Mitochondrial Function and Parkinson's Disease: From the Perspective of the Electron Transport Chain.
Li et al. (2021)
5 more

2 mentions without citation

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Vieweg et al. (2020)
1 more