› 6s2w

X-ray diffraction
1.95Å resolution

Structure of S. pombe Erh1, a protein important for meiotic mRNA decay in mitosis and meiosis progression.

Released:
DOI: 10.2210/pdb6s2w/pdb
PDB entry 6s2w coloured by chain, front view.
PDB entry 6s2w coloured by chain, side view.
PDB entry 6s2w coloured by chain, top view.
Source organism: Schizosaccharomyces pombe
Primary publication:
Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.
Hazra D, Andrić V, Palancade B, Rougemaille M, Graille M
Sci Rep 10 1034 (2020)
PMID: 31974447

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of rudimentary homolog 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 109 amino acids
Theoretical weight: 12.63 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli
UniProt:
  • Canonical: G2TRN4 (Residues: 1-104; Coverage: 100%)
Gene names: SPAC19G12.17, erh1, new10
Sequence domains: Enhancer of rudimentary

Ligands and Environments

4 bound ligands:
Ligand EDO 5 x EDO
Ligand TRS 1 x TRS
Ligand ACY 1 x ACY
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2221
Unit cell:
a: 71.845Å b: 123.847Å c: 68.144Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.232
Expression system: Escherichia coli

Quick links

Citations

4 review citations

ERH Gene and Its Role in Cancer Cells.
Pang et al. (2022)
3 more

1 mention without citation

Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.
Hazra et al. (2020)