› 6kn4

Solution NMR

HUMAN PARALLEL STRANDED 7-MER G-QUADRUPLEX COMPLEXED WITH 2 ADRIAMYCIN (DM2) MOLECULES

Released:
DOI: 10.2210/pdb6kn4/pdb
PDB entry 6kn4 coloured by chain, ensemble of 8 models, front view.
PDB entry 6kn4 coloured by chain, ensemble of 8 models, side view.
PDB entry 6kn4 coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug adriamycin.
Barthwal R, Raje S, Pandav K
J Biomol Struct Dyn 39 795-815 (2021)
PMID: 32070245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120160 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*TP*AP*GP*GP*GP*T)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 7 nucleotides
Theoretical weight: 2.17 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM2 2 x DM2
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 11%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

On the Road to Fight Cancer: The Potential of G-quadruplex Ligands as Novel Therapeutic Agents.
Alessandrini et al. (2021)
1 more

3 mentions without citation

Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures.
Criscuolo et al. (2022)
2 more