› 6jtg

X-ray diffraction
2.4Å resolution

Structural insights into G domain dimerization and pathogenic mutations of OPA1

Released:
DOI: 10.2210/pdb6jtg/pdb
PDB entry 6jtg coloured by chain, front view.
PDB entry 6jtg coloured by chain, side view.
PDB entry 6jtg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into G domain dimerization and pathogenic mutation of OPA1.
Yu C, Zhao J, Yan L, Qi Y, Guo X, Lou Z, Hu J, Rao Z
J Cell Biol 219 (2020)
PMID: 32379273

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-like GTPase OPA1, short form Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 38.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60313 (Residues: 263-571, 938-960; Coverage: 35%)
Gene names: KIAA0567, OPA1
Sequence domains: Dynamin family

Ligands and Environments

4 bound ligands:
Ligand GDP 1 x GDP
Ligand MG 1 x MG
Ligand BEF 1 x BEF
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 77.89Å b: 77.89Å c: 171.547Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.199 0.244
Expression system: Escherichia coli

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Citations

4 review citations

Mitochondrial dynamics proteins as emerging drug targets.
Zacharioudakis et al. (2023)
3 more

8 mentions without citation

Mitochondrial quality control in the brain: The physiological and pathological roles.
Shen et al. (2022)
7 more