› 6iwq

X-ray diffraction
2.95Å resolution

Crystal structure of GalNAc-T7 with Mn2+

Released:
DOI: 10.2210/pdb6iwq/pdb
PDB entry 6iwq coloured by chain, front view.
PDB entry 6iwq coloured by chain, side view.
PDB entry 6iwq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7.
Yu C, Liang L, Yin Y
Biochem Biophys Res Commun 510 266-271 (2019)
PMID: 30685086

Function and Biology Details

Reaction catalysed: 
UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetylgalactosaminyltransferase 7 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 597 amino acids
Theoretical weight: 68.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86SF2 (Residues: 61-657; Coverage: 91%)
Gene name: GALNT7
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MN 6 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 137.695Å b: 158.233Å c: 251.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.225 0.239
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health.
Garay et al. (2022)
5 other articles