› 6hrr

X-ray diffraction
2Å resolution

Structure of the TRPML2 ELD at pH 6.5

Released:
DOI: 10.2210/pdb6hrr/pdb
PDB entry 6hrr coloured by chain, front view.
PDB entry 6hrr coloured by chain, side view.
PDB entry 6hrr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
Structure 27 1246-1257.e5 (2019)
PMID: 31178222

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184970 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 191 amino acids
Theoretical weight: 22.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZK6 (Residues: 92-282; Coverage: 34%)
Gene name: MCOLN2
Sequence domains: Mucolipin, extracytosolic domain

Ligands and Environments

4 bound ligands:
Ligand K 1 x K
Ligand CL 3 x CL
Ligand GOL 11 x GOL
Ligand MES 3 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: I422
Unit cell:
a: 109.471Å b: 109.471Å c: 149.744Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.217
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
5 more

2 mentions without citation

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
1 more