6hbw Summary

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Crystal structure of deoxy-human hemoglobin beta6 glu->trp

The structure was published by Harrington, D.J., Adachi, K., and Royer Jr., W.E., in 1998 in a paper entitled "Crystal structure of deoxy-human hemoglobin beta6 Glu --> Trp. Implications for the structure and formation of the sickle cell fiber." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN ALPHA 1) and PROTEIN (HEMOGLOBIN BETA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN ALPHA 1) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN ALPHA 1) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN BETA) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN BETA) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN ALPHA 1) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN BETA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolsearch membranesearch cytosolic small ribosomal subunitsearch heme bindingsearch iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch small molecule metabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch transportsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch positive regulation of cell deathsearch oxidation-reduction processsearch
B, D (P68871) hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transportsearch receptor-mediated endocytosissearch bicarbonate transportsearch regulation of blood pressuresearch transportsearch nitric oxide transportsearch renal absorptionsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch oxidation-reduction processsearch small molecule metabolic processsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch