› 6fqz

X-ray diffraction
1.9Å resolution

Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate

Released:
DOI: 10.2210/pdb6fqz/pdb
PDB entry 6fqz coloured by chain, front view.
PDB entry 6fqz coloured by chain, side view.
PDB entry 6fqz coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
Haeussler K, Fritz-Wolf K, Reichmann M, Rahlfs S, Becker K
J Mol Biol 430 4049-4067 (2018)
PMID: 30098336

Function and Biology Details

Reaction catalysed: 
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-phosphogluconate dehydrogenase, decarboxylating Chains: A, B
Molecule details ›
Chains: A, B
Length: 468 amino acids
Theoretical weight: 53.06 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli M15
UniProt:
  • Canonical: Q8IKT2 (Residues: 1-468; Coverage: 100%)
Gene name: PF3D7_1454700
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 6PG 2 x 6PG
Ligand GOL 19 x GOL
Ligand PEG 4 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 99.66Å b: 99.66Å c: 180.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.229
Expression system: Escherichia coli M15

Quick links

Citations

4 citation in other articles

Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle.
Rangel et al. (2020)
3 more

2 mentions without citation

6-Phosphogluconate dehydrogenase and its crystal structures.
Hanau et al. (2022)
1 more