› 6e5k

Solution NMR

Heterogeneous-Backbone Mimics of a Designed Disulfide-Rich Protein: Aib turn, Aib helix, N-methyl hairpin

Released:
DOI: 10.2210/pdb6e5k/pdb
PDB entry 6e5k coloured by chain, ensemble of 10 models, front view.
PDB entry 6e5k coloured by chain, ensemble of 10 models, side view.
PDB entry 6e5k coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein.
Cabalteja CC, Mihalko DS, Horne WS
Chembiochem 20 103-110 (2019)
PMID: 30326175

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166649 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Designed peptide NC_HEE_D1: Aib turn, Aib helix, N-methyl hairpin mutant Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.16 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand AIB 4 x AIB
Ligand MVA 2 x MVA
Ligand DPR 1 x DPR

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.
Horne et al. (2020)
1 more

1 mention without citation

Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein.
Cabalteja et al. (2019)