› 6djz

X-ray diffraction
3.08Å resolution

Human sigma-1 receptor bound to haloperidol

Released:
DOI: 10.2210/pdb6djz/pdb
PDB entry 6djz coloured by chain, front view.
PDB entry 6djz coloured by chain, side view.
PDB entry 6djz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for σ1 receptor ligand recognition.
Schmidt HR, Betz RM, Dror RO, Kruse AC
Nat Struct Mol Biol 25 981-987 (2018)
PMID: 30291362

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sigma non-opioid intracellular receptor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 227 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q99720 (Residues: 1-223; Coverage: 100%)
Gene names: AAG8, OPRS1, SIGMAR1, SRBP
Sequence domains: ERG2 and Sigma1 receptor like protein

Ligands and Environments

4 bound ligands:
Ligand GMJ 3 x GMJ
Ligand SO4 15 x SO4
Ligand GOL 5 x GOL
Ligand OLC 7 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 85.556Å b: 126.062Å c: 109.702Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.239 0.276
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases.
Ryskamp et al. (2019)
13 more

15 mentions without citation

The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets.
Vitale et al. (2021)
14 more