› 6cyj

X-ray diffraction
2.7Å resolution

Mycobacterium tuberculosis transcriptional regulator

Released:
DOI: 10.2210/pdb6cyj/pdb
PDB entry 6cyj coloured by chain, front view.
PDB entry 6cyj coloured by chain, side view.
PDB entry 6cyj coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Tang S, Hicks ND, Cheng YS, Silva A, Fortune SM, Sacchettini JC
Nucleic Acids Res 47 9934-9949 (2019)
PMID: 31504787

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator PrpR Chains: A, B
Molecule details ›
Chains: A, B
Length: 429 amino acids
Theoretical weight: 47.66 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O06581 (Residues: 81-486; Coverage: 84%)
Gene names: P425_01178, RVBD_1129c, Rv1129c, prpR
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand SF4 2 x SF4
Ligand SCA 2 x SCA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P41212
Unit cell:
a: 144.485Å b: 144.485Å c: 96.187Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Transcriptional regulation and drug resistance in Mycobacterium tuberculosis.
Miotto et al. (2022)
1 more

2 mentions without citation

Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Tang et al. (2019)
1 more