› 6cm4

X-ray diffraction
2.87Å resolution

Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone

Released:
DOI: 10.2210/pdb6cm4/pdb
PDB entry 6cm4 coloured by chain, front view.
PDB entry 6cm4 coloured by chain, side view.
PDB entry 6cm4 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL
Nature 555 269-273 (2018)
PMID: 29466326

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132964 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D(2) dopamine receptor; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 430 amino acids
Theoretical weight: 48.88 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14416 (Residues: 35-222, 363-443; Coverage: 61%)
  • Canonical: P00720 (Residues: 2-162; Coverage: 98%)
Gene names: DRD2, E
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 8NU 1 x 8NU
Ligand PEG 3 x PEG
Ligand OLA 3 x OLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 50.979Å b: 72.523Å c: 151.307Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.226 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.
Martel et al. (2020)
24 more

106 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
105 more