6ca2 Summary



The structure was published by Alexander, R.S., Nair, S.K., and Christianson, D.W., in 1991 in a paper entitled "Engineering the hydrophobic pocket of carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch one-carbon metabolic processsearch secretionsearch regulation of anion transportsearch bicarbonate transportsearch response to organic substancesearch positive regulation of bone resorptionsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to zinc ionsearch kidney developmentsearch response to estrogensearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch apical part of cellsearch cytosolsearch plasma membranesearch basolateral plasma membranesearch cytoplasmsearch axonsearch microvillussearch myelin sheathsearch membranesearch extracellular vesicular exosomesearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch