› 6c2t

X-ray diffraction
1.73Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127238 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.44 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O14965 (Residues: 125-391; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand EGJ 1 x EGJ
Ligand DMS 1 x DMS
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P41212
Unit cell:
a: 83.487Å b: 83.487Å c: 74.766Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.22
Expression system: unidentified baculovirus

Quick links

Citations

42 review citations

Lineage plasticity in cancer: a shared pathway of therapeutic resistance.
Quintanal-Villalonga et al. (2020)
41 more

1 mention without citation

Antiproliferative Activity of a New Quinazolin-4(3H)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer.
Lee et al. (2022)