› 6bcq

Electron Microscopy
3.25Å resolution

cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom resolution

Released:
DOI: 10.2210/pdb6bcq/pdb
PDB entry 6bcq coloured by chain, front view.
PDB entry 6bcq coloured by chain, side view.
PDB entry 6bcq coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of the calcium-activated, non-selective cation channel TRPM4.
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature 552 205-209 (2017)
PMID: 29211714
Related structures: EMD-7085

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182020 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1254 amino acids
Theoretical weight: 140.92 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7TN37 (Residues: 1-1213; Coverage: 100%)
Gene names: Ltrpc4, Trpm4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 4 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.25Å
Relevant EMDB volumes: EMD-7085
Expression system: Homo sapiens

Quick links

Citations

35 review citations

Transient receptor potential channels in cardiac health and disease.
Hof et al. (2019)
34 more

4 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
3 more