Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Coagulation factor XIIa complex (preferred)
PDBe Complex ID:
PDB-CPX-133244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-factor XIIa part 1
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 932 Da
Source organism: Homo sapiens
UniProt:
Length: 9 amino acids
Theoretical weight: 932 Da
Source organism: Homo sapiens
UniProt:
- Canonical:
P00748 (Residues: 354-362; Coverage: 2%)
Coagulation factor XIIa light chain
Molecule details ›
Chain: B
Length: 243 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 243 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00748 (Residues: 373-615; Coverage: 41%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
