› 6avb

Electron Microscopy
3.9Å resolution

CryoEM structure of Mical Oxidized Actin (Class 1)

Released:
DOI: 10.2210/pdb6avb/pdb
PDB entry 6avb coloured by chain, front view.
PDB entry 6avb coloured by chain, side view.
PDB entry 6avb coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Catastrophic disassembly of actin filaments via Mical-mediated oxidation.
Grintsevich EE, Ge P, Sawaya MR, Yesilyurt HG, Terman JR, Zhou ZH, Reisler E
Nat Commun 8 2183 (2017)
PMID: 29259197
Related structures: EMD-7008

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159323 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 377 amino acids
Theoretical weight: 42.14 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 1-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 3 x ADP
2 modified residues:
Ligand SME 6 x SME
Ligand HIC 3 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-7008

Quick links

Citations

16 review citations

Regulation of actin isoforms in cellular and developmental processes.
Kashina AS. (2020)
15 more

2 mentions without citation

MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics.
Rajan et al. (2023)
1 more