› 6ap9

X-ray diffraction
1.55Å resolution

Crystal Structure of hGSTP1-1 with S-nitrosation of Cys101

Released:
DOI: 10.2210/pdb6ap9/pdb
PDB entry 6ap9 coloured by chain, front view.
PDB entry 6ap9 coloured by chain, side view.
PDB entry 6ap9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kumari V, Ji X

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09211 (Residues: 1-210; Coverage: 100%)
Gene names: FAEES3, GST3, GSTP1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GDS 2 x GDS

Cofactor: Ligand GSH 2 x GSH
3 bound ligands:
Ligand MES 2 x MES
Ligand ACT 2 x ACT
Ligand CA 5 x CA
1 modified residue:
Ligand SNC 2 x SNC

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 78.148Å b: 90.052Å c: 68.872Å
α: 90° β: 98.67° γ: 90°
R-values:
R R work R free
0.146 0.146 0.181
Expression system: Escherichia coli BL21(DE3)

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