6aek

X-ray diffraction
1.8Å resolution

Crystal structure of ENPP1 in complex with pApG

Released:

Function and Biology Details

Reactions catalysed:
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-139236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form Chain: A
Molecule details ›
Chain: A
Length: 738 amino acids
Theoretical weight: 84.82 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P06802 (Residues: 170-906; Coverage: 81%)
Gene names: Enpp1, Npps, Pc1, Pdnp1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 54.486Å b: 94.071Å c: 74.68Å
α: 90° β: 96.86° γ: 90°
R-values:
R R work R free
0.184 0.183 0.208
Expression system: Homo sapiens