PDB 6uok structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

Biochemical function:

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Biological process:

DNA biosynthetic process

Cellular component:

protein-containing complex

Sequence domains:

4 more domains

Structure analysis Details

Assembly composition:

hetero tetramer (preferred)

Assembly name:

DNA polymerase beta and DNA (preferred)

PDBe Complex ID:

PDB-CPX-120711 (preferred)

Entry contents:

1 distinct polypeptide molecule
3 distinct DNA molecules

Macromolecules (4 distinct):

DNA polymerase beta Chains: A, F

Molecule details ›

Chains: A, F
Length: 335 amino acids
Theoretical weight: 38.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P06746 (Residues: 1-335; Coverage: 100%)

Gene name: POLB
Sequence domains:

DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') Chains: B, T

Molecule details ›

Chains: B, T
Length: 16 nucleotides
Theoretical weight: 4.83 KDa
Source organism: synthetic construct
Expression system: Not provided

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3') Chains: C, P

Molecule details ›

Chains: C, P
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: synthetic construct
Expression system: Not provided

DNA (5'-D(P*GP*TP*CP*GP*G)-3') Chains: D, E

Molecule details ›

Chains: D, E
Length: 5 nucleotides
Theoretical weight: 1.54 KDa
Source organism: synthetic construct
Expression system: Not provided