› 5y7w

X-ray diffraction
2.25Å resolution

Crystal structure of the Nco-A1 PAS-B domain with YL-2

Released:
DOI: 10.2210/pdb5y7w/pdb
PDB entry 5y7w coloured by chain, front view.
PDB entry 5y7w coloured by chain, side view.
PDB entry 5y7w coloured by chain, top view.
Source organisms:
Primary publication:
Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.
Lee Y, Yoon H, Hwang SM, Shin MK, Lee JH, Oh M, Im SH, Song J, Lim HS
J Am Chem Soc 139 16056-16059 (2017)
PMID: 29090910

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.5 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P70365 (Residues: 257-367; Coverage: 8%)
Gene names: Ncoa1, Src1
Sequence domains: PAS domain
Structure domains: PAS domain
YL-2 peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.84 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand MK8 4 x MK8
Ligand ALC 2 x ALC

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P61
Unit cell:
a: 62.501Å b: 62.501Å c: 137.177Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.164 0.204
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Emerging Methods and Design Principles for Cell-Penetrant Peptides.
Peraro et al. (2018)
3 more

1 mention without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)