› 5xtw

X-ray diffraction
3.2Å resolution

Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH

Released:
DOI: 10.2210/pdb5xtw/pdb
PDB entry 5xtw coloured by chain, front view.
PDB entry 5xtw coloured by chain, side view.
PDB entry 5xtw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor.
Hu Z, Shi X, Yu B, Li N, Huang Y, He Y
Structure 26 60-71.e3 (2018)
PMID: 29225077

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage mannose receptor 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 475 amino acids
Theoretical weight: 54.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P22897 (Residues: 22-490; Coverage: 33%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MES 8 x MES
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: P1
Unit cell:
a: 43.819Å b: 164.768Å c: 164.596Å
α: 91.11° β: 97.56° γ: 97.5°
R-values:
R R work R free
0.212 0.211 0.248
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure.
Nielsen et al. (2020)
3 more

1 mention without citation

HumanLectome, an update of UniLectin for the annotation and prediction of human lectins.
Schnider et al. (2024)