› 5xqd

X-ray diffraction
1.6Å resolution

Crystal structure of Human Hsp90 with FS2

Released:
DOI: 10.2210/pdb5xqd/pdb
PDB entry 5xqd coloured by chain, front view.
PDB entry 5xqd coloured by chain, side view.
PDB entry 5xqd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li J, Shi F, Xiong B, He JH

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand 8CF 1 x 8CF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: I222
Unit cell:
a: 65.61Å b: 89.238Å c: 99.458Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.2
Expression system: Escherichia coli

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