› 5weo

Electron Microscopy
4.2Å resolution

Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin

Released:
DOI: 10.2210/pdb5weo/pdb
PDB entry 5weo coloured by chain, front view.
PDB entry 5weo coloured by chain, side view.
PDB entry 5weo coloured by chain, top view.
Source organisms:
Primary publication:
Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Nature 549 60-65 (2017)
PMID: 28737760
Related structures: EMD-8823

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131564 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2; Voltage-dependent calcium channel gamma-2 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1034 amino acids
Theoretical weight: 115.5 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: O88602 (Residues: 2-208; Coverage: 64%)
Gene names: Cacng2, GluA2, Glur2, Gria2, Stg
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GLU 4 x GLU
Ligand CYZ 4 x CYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-8823
Expression system: Homo sapiens

Quick links

Citations

26 review citations

Progress in nicotinic receptor structural biology.
Gharpure et al. (2020)
25 more

36 mentions without citation

Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.
Buonarati et al. (2019)
35 more