› 5vuc

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: B
Molecule details ›
Chain: B
Length: 298 amino acids
Theoretical weight: 34.2 KDa
Source organism: Homo sapiens
Expression system: Cell-free gateway cloning vector C-term 8xHis pCellFree_G02
UniProt:
  • Canonical: P11309 (Residues: 29-313; Coverage: 91%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand 8GR 1 x 8GR
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P65
Unit cell:
a: 98.37Å b: 98.37Å c: 80.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.175 0.199
Expression system: Cell-free gateway cloning vector C-term 8xHis pCellFree_G02

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Citations

12 citation in other articles

Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation.
Kato et al. (2020)
11 more