› 5tce

Solution NMR

N-terminal microdomain of 34-mers from HsDHODH - N-t(DH)

Released:
DOI: 10.2210/pdb5tce/pdb
PDB entry 5tce coloured by chain, ensemble of 20 models, front view.
PDB entry 5tce coloured by chain, ensemble of 20 models, side view.
PDB entry 5tce coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes of the HsDHODH N-terminal Microdomain via DEER Spectroscopy.
Vicente EF, Sahu ID, Costa-Filho AJ, Cilli EM, Lorigan GA
J Phys Chem B 119 8693-7 (2015)
PMID: 26086954

Function and Biology Details

Reaction catalysed: 
(S)-dihydroorotate + a quinone = orotate + a quinol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroorotate dehydrogenase (quinone), mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q02127 (Residues: 32-65; Coverage: 9%)
Gene name: DHODH

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 67%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

Site-Directed Spin Labeling EPR for Studying Membrane Proteins.
Sahu et al. (2018)
2 more

1 mention without citation

Virtual Screening Technique Used to Estimate the Mechanism of Adhatoda vasica Nees for the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking.
Wang et al. (2020)