› 5t4r

Solution NMR

NMR solution structure of the Nav1.7 selective spider venom-derived peptide Pn3a

Released:
DOI: 10.2210/pdb5t4r/pdb
PDB entry 5t4r coloured by chain, ensemble of 20 models, front view.
PDB entry 5t4r coloured by chain, ensemble of 20 models, side view.
PDB entry 5t4r coloured by chain, ensemble of 20 models, top view.
Source organism: Theraphosidae
Primary publication:
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I
Sci Rep 7 40883 (2017)
PMID: 28106092

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166098 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Pn3a Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.29 KDa
Source organism: Theraphosidae
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 69%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

24 review citations

Etiology and Pharmacology of Neuropathic Pain.
Alles et al. (2018)
23 more

9 mentions without citation

Antibodies and venom peptides: new modalities for ion channels.
Wulff et al. (2019)
8 more