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X-ray diffraction
2.48Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isocitrate dehydrogenase [NADP] cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 417 amino acids
Theoretical weight: 46.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75874 (Residues: 1-414; Coverage: 100%)
Gene names: IDH1, PICD
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Structure domains: Isopropylmalate Dehydrogenase

Ligands and Environments


Cofactor: Ligand NDP 2 x NDP
4 bound ligands:
Ligand 70Q 2 x 70Q
Ligand SO4 4 x SO4
Ligand EDO 2 x EDO
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P43212
Unit cell:
a: 82.563Å b: 82.563Å c: 302.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.221
Expression system: Escherichia coli

Quick links

Citations

8 review citations

2-Hydroxyglutarate in Cancer Cells.
Ježek P. (2020)
7 more

3 mentions without citation

The content of phenolic compounds and radical scavenging activity varies with carrot origin and root color.
Leja et al. (2013)
2 more