› 5s79

X-ray diffraction
1.5Å resolution

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010910a

Released:
DOI: 10.2210/pdb5s79/pdb
PDB entry 5s79 coloured by chain, front view.
PDB entry 5s79 coloured by chain, side view.
PDB entry 5s79 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Williams EP, Adamson RJ, Smil D, Krojer T, Burgess-Brown N, von Delft F, Bountra C, Bullock AN

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activin receptor type-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04771 (Residues: 201-499; Coverage: 61%)
Gene names: ACVR1, ACVRLK2
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

5 bound ligands:
Ligand LU8 4 x LU8
Ligand EDO 12 x EDO
Ligand DMS 2 x DMS
Ligand SO4 5 x SO4
Ligand PZO 4 x PZO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 127.417Å b: 84.841Å c: 87.911Å
α: 90° β: 131.01° γ: 90°
R-values:
R R work R free
0.18 0.179 0.206
Expression system: Spodoptera frugiperda

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