5pnt Summary

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CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY

The structure was published by Zhang, M., Stauffacher, C.V., Lin, D., and Van Etten, R.L., in 1998 in a paper entitled "Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. This molecule has the UniProt identifier P24666 (PPAC_HUMAN)search. The sample contained 157 residues which is 99% of the natural sequence. Out of 157 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE P24666 (2-158) (PPAC_HUMAN)search Homo sapienssearch 99% 157 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24666 (2 - 158) LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24666) Low-molecular-weight phosphotyrosine protein phosphatasessearch Rossmann foldsearch PF01451: Low molecular weight phosphotyrosine protein phosphatasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24666) acid phosphatase activitysearch protein tyrosine phosphatase activitysearch non-membrane spanning protein tyrosine phosphatase activitysearch phosphatase activitysearch protein bindingsearch SH3 domain bindingsearch phosphoprotein phosphatase activitysearch hydrolase activitysearch cytoplasmsearch neuron projectionsearch nucleussearch internal side of plasma membranesearch protein dephosphorylationsearch synaptic transmissionsearch peptidyl-tyrosine dephosphorylationsearch

Chain InterPro annotation
A Protein-tyrosine phosphatase/arsenate reductasesearch Protein-tyrosine phosphatase, low molecular weight, mammaliansearch Protein-tyrosine phosphatase, low molecular weightsearch Phosphotyrosine protein phosphatase I superfamilysearch