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CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY

X-ray diffraction
2.2Å resolution
PDB entry 5pnt coloured by chain, front view.
PDB entry 5pnt coloured by chain, side view.
PDB entry 5pnt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Low molecular weight phosphotyrosine protein phosphatase
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Multimeric state: monomeric
Accessible surface area: 8160.46 Å2
Buried surface area: 425.21 Å2
Dissociation area: 212.6 Å2
Dissociation energy (ΔGdiss): -5.2 kcal/mol
Dissociation entropy (TΔSdiss): 2.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150269

Macromolecules

Low molecular weight phosphotyrosine protein phosphatase
Chain: A
Length: 157 amino acids
Theoretical weight: 17.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P24666 (Residues: 2-158; Coverage: 99%)
Gene name: ACP1
Pfam: Low molecular weight phosphotyrosine protein phosphatase
InterPro:
CATH: Rossmann fold
SCOP: Low-molecular-weight phosphotyrosine protein phosphatases
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 5pnt, assembly 1, front view.
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 5pnt, assembly 1, side view.
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 5pnt, assembly 1, top view.
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