› 5nq4

Solution NMR

Cytotoxin-1 in DPC-micelle

Released:
DOI: 10.2210/pdb5nq4/pdb
PDB entry 5nq4 coloured by chain, ensemble of 20 models, front view.
PDB entry 5nq4 coloured by chain, ensemble of 20 models, side view.
PDB entry 5nq4 coloured by chain, ensemble of 20 models, top view.
Source organism: Naja oxiana
Primary publication:
Impact of membrane partitioning on the spatial structure of an S-type cobra cytotoxin.
Dubovskii PV, Dubinnyi MA, Volynsky PE, Pustovalova YE, Konshina AG, Utkin YN, Arseniev AS, Efremov RG
J Biomol Struct Dyn 36 3463-3478 (2018)
PMID: 28990854

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxin 1 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.83 KDa
Source organism: Naja oxiana
Expression system: Naja oxiana
UniProt:
  • Canonical: P01451 (Residues: 1-60; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Naja oxiana

Quick links

Citations

2 review citations

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy.
Kalita et al. (2022)
1 more

1 mention without citation

Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii et al. (2022)