› 5myv

X-ray diffraction
2.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SRSF protein kinase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 389 amino acids
Theoretical weight: 44.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78362 (Residues: 51-688; Coverage: 56%)
Gene name: SRPK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 48 x SO4
Ligand W4A 4 x W4A
Ligand DMS 3 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 188.79Å b: 248.99Å c: 146.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.217
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Kinase inhibitors: the road ahead.
Ferguson et al. (2018)
13 more

1 mention without citation

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA.
Sun et al. (2019)