› 5l23

X-ray diffraction
1.77Å resolution

Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand

Released:
DOI: 10.2210/pdb5l23/pdb
PDB entry 5l23 coloured by chain, front view.
PDB entry 5l23 coloured by chain, side view.
PDB entry 5l23 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Bhatt VS, Krieger I, Sacchettini J, Cho J-H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171833 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adapter molecule crk Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.97 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q64010 (Residues: 134-191; Coverage: 19%)
Gene names: Crk, Crko
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Rap guanine nucleotide exchange factor 1 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.72 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q13905 (Residues: 279-293; Coverage: 1%)
Gene names: GRF2, RAPGEF1

Ligands and Environments

1 bound ligand:
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 27.6Å b: 41.34Å c: 56.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.21
Expression systems:
  • Escherichia coli
  • Not provided

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