› 5kwv

X-ray diffraction
2.25Å resolution

Crystal Structure of a Pantoate-beta-alanine Ligase from Neisseria gonorrhoeae with bound AMPPNP

Released:
DOI: 10.2210/pdb5kwv/pdb
PDB entry 5kwv coloured by chain, front view.
PDB entry 5kwv coloured by chain, side view.
PDB entry 5kwv coloured by chain, top view.
Source organism: Neisseria gonorrhoeae NCCP11945
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.05 KDa
Source organism: Neisseria gonorrhoeae NCCP11945
Expression system: Escherichia coli
UniProt:
  • Canonical: B4RKE7 (Residues: 2-259; Coverage: 100%)
Gene names: NGK_0607, panC
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P41212
Unit cell:
a: 137.65Å b: 137.65Å c: 73.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.219
Expression system: Escherichia coli

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