5jkc

X-ray diffraction
2.9Å resolution

Crystal structure of human IZUMO1-JUNO complex (crystal form 1)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-107989 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Izumo sperm-egg fusion protein 1 Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q8IYV9 (Residues: 22-255; Coverage: 71%)
Gene name: IZUMO1
Sequence domains:
Sperm-egg fusion protein Juno Chain: B
Molecule details ›
Chain: B
Length: 221 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: A6ND01 (Residues: 20-228; Coverage: 91%)
Gene names: FOLR4, IZUMO1R, JUNO
Sequence domains: Folate receptor family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: C2221
Unit cell:
a: 65.188Å b: 144.75Å c: 141.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.259
Expression system: Drosophila