Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- mRNA cap 0/1 methyltransferase
- RNA-directed RNA polymerase, thumb subdomain, flavivirus
- RNA-directed RNA polymerase, catalytic domain
- RNA-dependent RNA polymerase, flavivirus
- DNA/RNA polymerase superfamily
- RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus
- Ribosomal RNA methyltransferase, FtsJ domain
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
RNA-directed RNA polymerase NS5 (preferred)
PDBe Complex ID:
PDB-CPX-180557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase NS5
Molecule details ›
Chain: A
Length: 892 amino acids
Theoretical weight: 102.83 KDa
Source organism: Dengue virus 3
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 892 amino acids
Theoretical weight: 102.83 KDa
Source organism: Dengue virus 3
Expression system: Escherichia coli
UniProt:
- Canonical:
Q6YMS4 (Residues: 2494-3385; Coverage: 26%)
Sequence domains:
