› 5i4z

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133951 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myc proto-oncogene protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 14.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01106 (Residues: 363-454; Coverage: 20%)
Gene names: BHLHE39, MYC
Sequence domains:
Structure domains: Helix-loop-helix DNA-binding domain

Ligands and Environments

3 bound ligands:
Ligand GOL 3 x GOL
Ligand CL 3 x CL
Ligand K 2 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P4122
Unit cell:
a: 65.7Å b: 65.7Å c: 149.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.194
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
Madden et al. (2021)
19 more

10 mentions without citation

Targeting intrinsically disordered proteins involved in cancer.
Santofimia-Castaño et al. (2020)
9 more