› 5i04

X-ray diffraction
2.42Å resolution

Crystal structure of the orphan region of human endoglin/CD105

Released:
DOI: 10.2210/pdb5i04/pdb
PDB entry 5i04 coloured by chain, front view.
PDB entry 5i04 coloured by chain, side view.
PDB entry 5i04 coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L
Cell Rep 19 1917-1928 (2017)
PMID: 28564608

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142519 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Endoglin; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 692 amino acids
Theoretical weight: 75.25 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0AEX9 (Residues: 27-393; Coverage: 99%)
  • Canonical: P17813 (Residues: 26-337; Coverage: 49%)
Gene names: END, ENG, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand PGE 3 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P65
Unit cell:
a: 114.15Å b: 114.15Å c: 120.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.263
Expression system: Homo sapiens

Quick links

Citations

25 review citations

Contextual determinants of TGFβ action in development, immunity and cancer.
David et al. (2018)
24 more

2 mentions without citation

Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family.
Kim et al. (2019)
1 more