› 5gns

X-ray diffraction
2.7Å resolution

Structures of human Mitofusin 1 provide insight into mitochondrial tethering

Released:
DOI: 10.2210/pdb5gns/pdb
PDB entry 5gns coloured by chain, front view.
PDB entry 5gns coloured by chain, side view.
PDB entry 5gns coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qi Y, Yan L, Yu C, Guo X, Zhou X, Hu X, Huang X, Rao Z, Lou Z, Hu J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitofusin-1 Chain: A
Molecule details ›
Chain: A
Length: 421 amino acids
Theoretical weight: 47.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWA4 (Residues: 1-364; Coverage: 49%)
Gene name: MFN1
Sequence domains: Dynamin family

Ligands and Environments

1 bound ligand:
Ligand GTP 1 x GTP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 71.657Å b: 74.671Å c: 94.756Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.212 0.283
Expression system: Escherichia coli

Quick links

Citations

46 review citations

The cell biology of mitochondrial membrane dynamics.
Giacomello et al. (2020)
45 more

6 mentions without citation

Structures of human mitofusin 1 provide insight into mitochondrial tethering.
Qi et al. (2016)
5 more