› 5e5e

X-ray diffraction
1.98Å resolution

X-ray structure of the adduct formed in the reaction between RNase A and a neutral organometallic derivative [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3)

Released:
DOI: 10.2210/pdb5e5e/pdb
PDB entry 5e5e coloured by chain, front view.
PDB entry 5e5e coloured by chain, side view.
PDB entry 5e5e coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Cytotoxic properties of a new organometallic platinum(II) complex and its gold(I) heterobimetallic derivatives.
Serratrice M, Maiore L, Zucca A, Stoccoro S, Landini I, Mini E, Massai L, Ferraro G, Merlino A, Messori L, Cinellu MA
Dalton Trans 45 579-90 (2016)
PMID: 26609781

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:
Ligand PT 2 x PT
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 100.398Å b: 32.768Å c: 72.54Å
α: 90° β: 89.82° γ: 90°
R-values:
R R work R free
0.195 0.192 0.254

Quick links

Citations

2 review citations

Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?
Yeo et al. (2018)
1 more