› 5coy

X-ray diffraction
1.44Å resolution

Crystal structure of CC chemokine 5 (CCL5)

Released:
DOI: 10.2210/pdb5coy/pdb
PDB entry 5coy coloured by chain, front view.
PDB entry 5coy coloured by chain, side view.
PDB entry 5coy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Liang WG, Triandafillou CG, Huang TY, Zulueta MM, Banerjee S, Dinner AR, Hung SC, Tang WJ
Proc Natl Acad Sci U S A 113 5000-5 (2016)
PMID: 27091995

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
C-C motif chemokine 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 65 amino acids
Theoretical weight: 7.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13501 (Residues: 27-91; Coverage: 96%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC, Z9N
Carbohydrate polymer
2 bound ligands:
Ligand PO4 2 x PO4
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 23.601Å b: 56.196Å c: 94.168Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.155 0.192
Expression system: Escherichia coli

Quick links

Citations

14 review citations

A guide to chemokines and their receptors.
Hughes et al. (2018)
13 more

13 mentions without citation

Chemokines from a Structural Perspective.
Miller et al. (2017)
12 more